Sodium danshensu Chemical Properties

storage temp. 

Inert atmosphere,2-8°C

solubility 

H2O : 100 mg/mL (454.24 mM; Need ultrasonic)DMSO : 100 mg/mL (454.24 mM; Need ultrasonic)

form 

powder

color 

White-beige

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

24/25

HS Code 

29329990

Sodium danshensu Usage And Synthesis

Description

Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities. It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury. Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction. It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model. Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.

Chemical Properties

White to light brown powder

Uses

Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain.

target

Calcium Channel | Potassium Channel | Akt | GSK-3 | Bcl-2/Bax | PI3K

Sodium danshensu(67920-52-9)Related Product Information

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