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(-)-Nebivolol

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(-)-Nebivolol Basic information

Product Name:
(-)-Nebivolol
Synonyms:
  • (aS,a,2R,2)-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
  • (2R)-2-[(S)-1-Hydroxy-2-[[(S)-2-hydroxy-2-[[(2S)-3,4-dihydro-6-fluoro-2H-1-benzopyran]-2-yl]ethyl]amino]ethyl]-6-fluoro-3,4-dihydro-2H-1-benzopyran
  • [2R,2'S,αS,α'S,(-)]-α,α'-[Iminobis(methylene)]bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
  • (αS,α'S,2R,2'S)-α,α'-[IMinobis(Methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-Methanol]
  • [2S-[2R*[R*[R*(S*)]]]]-α,α'-[IMinobis(Methylene)]bis[6-fluoro-3,4-dihydro- 2H-1-benzopyran-2-Methanol
  • Levonebivolol
  • Nebivolol IMpurity A (L-Nebivolol)
  • l-Nebivolol
CAS:
118457-16-2
MF:
C22H25F2NO4
MW:
405.43
Product Categories:
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
118457-16-2.mol
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(-)-Nebivolol Chemical Properties

Melting point:
135-137°C
Boiling point:
600.5±55.0 °C(Predicted)
Density 
1.309±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.29±0.20(Predicted)
color 
White to Off-White
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(-)-Nebivolol Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

A β1-Adrenergic blocker. Used as an antihypertensive.

Uses

(-)-Nebivolol is a β1-Adrenergic blocker. Used as an antihypertensive.

Definition

ChEBI: A 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] that has (1S,1'S,2R,2'S)-configuration.

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