Tigemonam
Tigemonam Basic information
- Product Name:
- Tigemonam
- Synonyms:
-
- Tigemonam
- [[[(Z)-1-(2-Aminothiazol-4-yl)-2-[[(3S)-2,2-dimethyl-4-oxo-1-(sulfooxy)azetidin-3-yl]amino]-2-oxoethylidene]amino]oxy]acetic acid
- Antibiotic SQ-30213
- SQ-30213
- Sulfuric acid [(3S)-3-[[2-(2-aminothiazol-4-yl)-2-[(Z)-carboxymethyloxyimino]-1-oxyethyl]amino]-4,4-dimethyl-2-oxoazetidin-1-yl] ester
- Tigemom
- Acetic acid, 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-[[(3S)-2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-
- 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(3S)-2,2-dimethyl-4-oxo-1-sulfooxyazetidin-3-yl]amino]-2-oxoethylidene]amino]oxyaceticaci
- CAS:
- 102507-71-1
- MF:
- C12H15N5O9S2
- MW:
- 437.41
- Mol File:
- 102507-71-1.mol
Tigemonam Chemical Properties
- Density
- 1.91±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- -3?+-.0.18(Predicted)
Tigemonam Usage And Synthesis
Definition
ChEBI: Tigemonam is a monobactam.
Clinical Use
Tigemonam is a newer monobactam that is orally active.It is highly resistant to β-lactamases. The antibacterialspectrum of activity resembles that of aztreonam. It is veryactive against the Enterobacteriaceae, including E. coli,Klebsiella, Proteus, Citrobacter, Serratia, and Enterobacterspp. It also exhibits good potency against H. influenzae andN. gonorrhoeae. Tigemonam is not particularly activeagainst Gram-positive or anaerobic bacteria and is inactiveagainst P. aeruginosa.
In contrast to the poor oral bioavailability of aztreonam,the oral absorption of tigemonam is excellent. Itcould become a valuable agent for the oral treatment ofurinary tract infections and other non–life-threatening infectionscaused by β-lactamase–producing Gram-negativebacteria.
TigemonamSupplier
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