1-NAPHTHOL-3,6,8-TRISULFONIC ACID TRISODIUM SALT Chemical Properties

form 

Solid

color 

Light yellow to light brown

1-NAPHTHOL-3,6,8-TRISULFONIC ACID TRISODIUM SALT Usage And Synthesis

Uses

ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].

IC 50

aPKC-ζ: 5 μM (IC₅₀)

References

[1] Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. DOI:10.1080/19336918.2018.1471323
[2] Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665. DOI:10.1016/j.biopha.2019.109665

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