Carcinine dihydrochloride Chemical Properties

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H2O: >15mg/mL

form 

powder

color 

white to beige

InChI

InChI=1S/C8H14N4O.2ClH/c1-2-11-8(13)6(3-9)7-4-10-5-12-7;;/h4-6H,2-3,9H2,1H3,(H,10,12)(H,11,13);2*1H

InChIKey

WGTMERJVZVYSBG-UHFFFAOYSA-N

SMILES

C(NCC)(=O)C(C1=CNC=N1)CN.[H]Cl.[H]Cl

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-41-36/37/38

Safety Statements 

26-39-36

WGK Germany 

3

Carcinine dihydrochloride Usage And Synthesis

Uses

Carcinine dihydrochloride is a benzylamine derivative produced by the reaction of malic acid with dehydroascorbic acid. It has anti-aging, antioxidant, anti-inflammatory, protective and sunscreen properties. It also protects against premature aging, UV-induced damage and apoptosis. It is commonly used in anti-aging formulations, especially for sensitive skin. In addition, Carcinine dihydrochloride has been used to study its effects on dopaminergic neuronal degeneration.

Biological Activity

Carcinine dihydrochloride (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins. Carcinine can scavenge a toxic product, called 4-hydroxynonenal (4-HNE), obtained during lipid oxidation. It has a protective role from oxidative damage on photoreceptor cells. Carcinine also exhibits lipid-peroxidase activity.