Teicoplanin A2-5 Chemical Properties

Density 

1.67±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide

form 

lyophilisate

pka

2.88±0.40(Predicted)

Teicoplanin A2-5 Usage And Synthesis

Uses

Teicoplanin A2-5 is an antibiotic against Gram positive bacteria.

Uses

Teicoplanin A2-5 is the most non-polar analogue of a family of lipoglycopeptides produced by Actinoplanes teichomyceticus. Teicoplanins possess potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis.

Definition

ChEBI: A teicoplanin A2 that has 9-methyldecanoyl as the variable N-acyl group.

Biological Activity

teicoplanin a2-5, derived from actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria.teicoplanin a2-5 is the most non-polar metabolite in the family of teicoplanins. teicoplanin, previously referred to in the literature as teichomycin, is a mixture of five closely related components of similar polarity, designated t-a2-1, 2, 3, 4 and 5 and of one more polar component, designated t-a3. additionally, as a glycopeptide antibiotic belonging to the same family as vancomycin, teicoplanin blocks cell wall synthesis in bacillus subtilis, which is accompanied by an intracellular accumulation of udp-n-acetylmuramyl-pentapetide [1]. due to the greater antibacterial activity of teicoplanin than other agents, it has been thoroughly studied as a β-1actamase-resistant agent for the treatment of human infections caused by streptococci and staphylococci, including enterococci [2].

References

[1]. somma, s., gastaldo, l., & corti, a. teicoplanin, a new antibiotic from actinoplanes teichomyceticus nov. sp. antimicrobial agents and chemotherapy. 1984; 26(6): 917-923.
[2]. traina, g., & bonati, m. pharmacokinetics of teicoplanin in man after intravenous administration. journal of pharmacokinetics and biopharmaceutics. 1984;12(2): 119-128.

Teicoplanin A2-5(91032-38-1)Related Product Information

• Teicoplanin A2
• Teicoplanin