2'-Deoxy-L-guanosine Chemical Properties

Density 

2.08±0.1 g/cm3(Predicted)

pka

9?+-.0.20(Predicted)

form 

Solid

color 

White to off-white

2'-Deoxy-L-guanosine Usage And Synthesis

Description

2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death. This is done by binding to the ribose phosphate backbone of DNA, phosphorylating it, and preventing the base pairing of adenosine with thymine. 2'-Deoxy-L-guanosine shows a high level of resistance against bacteria and is effective in the treatment of gram-positive bacteria.

Uses

2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine.html" class="link-product" target="_blank">2'-Deoxyguanosine (HY-17563)[1].

References

[1] Spadari S, et al. L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth. J Med Chem. 1992 Oct 30;35(22):4214-20. DOI:10.1021/jm00100a029

2'-Deoxy-L-guanosine(22837-44-1)Related Product Information

• 2'-DEOXY-L-URIDINE
• Thymidine
• 2'-DEOXY-L-CYTIDINE
• 2'-DEOXY-B-L-ADENOSINE
• 2,2'-Cyclouridine
• idoxuridine
• Uridine
• 2'-DEOXY-L-GUANOSINE-5'-TRIPHOSPHATE LITHIUM SALT
• 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine
• 2'-Deoxy-L-guanosine
• Pyrrolo[2,3-d]pyrimidin-4-ol