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Indinavir sulfate

Basic information Safety Supplier Related

Indinavir sulfate Basic information

Product Name:
Indinavir sulfate
Synonyms:
  • CRIXIVAN
  • INDINAVIR SULFATE
  • INDINAVIR SULPHATE
  • (1(1s,2r),5(s))-2,3,5-trideoxy-n-(2,3-dihydro-2-hydroxy-1h-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-d-erythro-pentonamide sulfate
  • MK-639
  • indinavirsulfate(subjecttopatentfree)
  • IDV
  • MK-639,Crixivan
CAS:
157810-81-6
MF:
C36H49N5O8S
MW:
711.87
EINECS:
682-418-9
Product Categories:
  • Active Pharmaceutical Ingredients
  • Indinavir
  • Anti-viral Compounds
  • Anti-virals
  • peptides
  • Other APIs
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Non-nucleoside Reverse Transcriptase
  • Pharmaceuticals
  • Coronavirus
Mol File:
157810-81-6.mol
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Indinavir sulfate Chemical Properties

Melting point:
150-153°C (dec)
storage temp. 
-20°C Freezer
solubility 
Freely soluble in water, soluble in methanol, practically insoluble in heptane.
form 
Solid
color 
White to Off-White
Water Solubility 
>100g/L(temperature not stated)
BCS Class
2,4
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Safety Information

Hazardous Substances Data
157810-81-6(Hazardous Substances Data)
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Indinavir sulfate Usage And Synthesis

Description

Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively). Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM). Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.

Chemical Properties

Crystalline Solid

Uses

Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product.

Definition

ChEBI: Indinavir sulfate is an azaheterocycle sulfate salt. It is functionally related to an indinavir.

brand name

Crixivan (Merck).

Hazard

Moderately toxic by ingestion.

storage

RT

Indinavir sulfateSupplier

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