Indinavir sulfate
Indinavir sulfate Basic information
- Product Name:
- Indinavir sulfate
- Synonyms:
-
- CRIXIVAN
- INDINAVIR SULFATE
- INDINAVIR SULPHATE
- (1(1s,2r),5(s))-2,3,5-trideoxy-n-(2,3-dihydro-2-hydroxy-1h-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-d-erythro-pentonamide sulfate
- MK-639
- indinavirsulfate(subjecttopatentfree)
- IDV
- MK-639,Crixivan
- CAS:
- 157810-81-6
- MF:
- C36H49N5O8S
- MW:
- 711.87
- EINECS:
- 682-418-9
- Product Categories:
-
- Active Pharmaceutical Ingredients
- Indinavir
- Anti-viral Compounds
- Anti-virals
- peptides
- Other APIs
- Inhibitors
- Intermediates & Fine Chemicals
- Non-nucleoside Reverse Transcriptase
- Pharmaceuticals
- Coronavirus
- Mol File:
- 157810-81-6.mol
Indinavir sulfate Chemical Properties
- Melting point:
- 150-153°C (dec)
- storage temp.
- -20°C Freezer
- solubility
- Freely soluble in water, soluble in methanol, practically insoluble in heptane.
- form
- Solid
- color
- White to Off-White
- Water Solubility
- >100g/L(temperature not stated)
- BCS Class
- 2,4
Safety Information
- Hazardous Substances Data
- 157810-81-6(Hazardous Substances Data)
Indinavir sulfate Usage And Synthesis
Description
Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively). Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM). Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.
Chemical Properties
Crystalline Solid
Uses
Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product.
Definition
ChEBI: Indinavir sulfate is an azaheterocycle sulfate salt. It is functionally related to an indinavir.
brand name
Crixivan (Merck).
Hazard
Moderately toxic by ingestion.
storage
RT
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Indinavir sulfate(157810-81-6)Related Product Information
- Zinc sulphate
- Barium sulfate
- Dimethyl sulfate
- Sodium thiosulfate pentahydrate
- Metformin
- Magnesium sulfate heptahydrate
- Ammonium sulfate
- Sodium sulfate
- Magnesium sulfate
- Dimethyl carbonate
- Dimethyl fumarate
- Dibutyl phthalate
- Indinavir
- CHLOROPHOSPHONAZO III
- Copper(II) sulfate
- Dimethylamine
- Aluminum sulfate
- Ferrous sulfate heptahydrate