N-Cbz-L-Aspartic acid 4-tert-butyl ester Chemical Properties

Boiling point:

513.1±50.0 °C(Predicted)

Density 

1.219±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

Soluble in DMSO, and methanol.

pka

3.67±0.23(Predicted)

form 

Powder

color 

White to off-white

optical activity

29°(C=0.01g/mL, CHCL3, 20°C, 589nm)

BRN 

2569846

InChI

InChI=1S/C16H21NO6/c1-16(2,3)23-13(18)9-12(14(19)20)17-15(21)22-10-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,17,21)(H,19,20)/t12-/m0/s1

InChIKey

HLSLRFBLVZUVIE-LBPRGKRZSA-N

SMILES

C(O)(=O)[C@H](CC(OC(C)(C)C)=O)NC(OCC1=CC=CC=C1)=O

CAS DataBase Reference

5545-52-8(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29224999

MSDS

• Language:English Provider:SigmaAldrich

N-Cbz-L-Aspartic acid 4-tert-butyl ester Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

It is a pharmaceutical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

The general procedure for the synthesis of (S)-3-(((benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid, N-benzyloxycarbonyl-L-aspartic acid 4-tert-butyl ester and Z-L-aspartic acid tert-butyl ester tert-butyl ester, using tert-butyl acetate and N-CBZ-L-aspartic acid, is as follows: an ester-exchange reaction system was set up according to the methodology described in Example 1 , but BF3 -Et2O was replaced with other catalysts. The catalysts tested included acids or salts as listed in Table I. The reaction was carried out at room temperature or at about 50°C for 5.5 to 15 hours. At the end of the reaction, the reaction mixtures were analyzed by HPLC technique as in Example 1. The results of Table I show that the ester exchange reaction in the presence of catalysts such as concentrated sulfuric acid (H2SO4), methanesulfonic acid (MsOH), zinc chloride (ZnCl2), and titanium tetrachloride in dichloromethane (TiCl4 in DCM), significantly produced Z-Asp(OtBu)2. In contrast, the catalytic effect of aluminum chloride (AlCl3), ferric chloride (FeCl3) and titanium tetraisopropoxide (Ti[OiPr]4) was not significant even under the conditions of increasing the reaction temperature and prolonging the reaction time.

References

[1] Patent: US2003/236430, 2003, A1. Location in patent: Page 3
[2] Patent: US2003/236430, 2003, A1. Location in patent: Page 3
[3] Patent: US2003/236430, 2003, A1. Location in patent: Page 3
[4] Patent: US2003/236430, 2003, A1. Location in patent: Page 3
[5] Patent: US2003/236430, 2003, A1. Location in patent: Page 3

N-Cbz-L-Aspartic acid 4-tert-butyl ester(5545-52-8)Related Product Information

• Dibutyl phthalate
• BUTYL OLEATE
• Buprofezin
• Methyl acrylate
• Cyhalofop-butyl
• Tris(trimethylsilyl)phosphate
• N-Carbobenzyloxyglycine
• Sodium L-aspartate
• L-Aspartic acid
• L-ASPARTIC ACID
• Z-ASP(OTBU)-OH DCHA
• N-Carbobenzyloxy-L-aspartic acid
• Z-ASP-OME
• N-Benzyloxycarbonyl-L-asparagine
• Z-Asp(OtBu)-Glu(OtBu)-OH
• N-Cbz-L-Aspartic acid 4-benzyl ester
• Z-Asp(OtBu)-His(Trt)-OH
• Z-ASP(OME)-OH