Salicylanilide Chemical Properties

Melting point:

136-138 °C (lit.)

Boiling point:

353.22°C (rough estimate)

Density 

1.1544 (rough estimate)

bulk density

455kg/m3

refractive index 

1.5700 (estimate)

storage temp. 

Store below +30°C.

solubility 

H2O: slightly soluble

form 

buffered aqueous glycerol solution

pka

7.11±0.10(Predicted)

color 

White to Almost white

PH

7-7.5 (50g/l, H2O, 25℃)

biological source

goat

Water Solubility 

SLIGHTLY SOLUBLE

Merck 

14,8330

BRN 

1108135

InChI

1S/C13H11NO2/c15-12-9-5-4-8-11(12)13(16)14-10-6-2-1-3-7-10/h1-9,15H,(H,14,16)

InChIKey

WKEDVNSFRWHDNR-UHFFFAOYSA-N

SMILES

Oc1ccccc1C(=O)Nc2ccccc2

CAS DataBase Reference

87-17-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzamide, 2-hydroxy-N-phenyl-(87-17-2)

EPA Substance Registry System

Salicylanilide (87-17-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

2

RTECS 

VN7850000

Autoignition Temperature

>300 °C

TSCA 

TSCA listed

HazardClass 

9

HS Code 

29242995

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Chronic 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:N-Phenylsalicylamide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Salicylanilide Usage And Synthesis

Chemical Properties

greyish-brownish powder

Uses

antipyretic, fungicide

Uses

Anti-mildew, fungicide.

Uses

Salicylanilides are compounds of varying biological activity ranging from anti-inflammatory agents to antiviral and antimicrobial agents.

Definition

ChEBI: An amide of salicylic acid and of aniline; it is therefore both a salicylamide and an anilide.

General Description

Salicylanilide inhibited mycobacterial isocitrate lyase (ICL) and showed a significant antimycobacterial effect.

Hazard

Toxic by ingestion, irritant to skin.

Synthesis

Method for catalyzing the carbonylation of halogenated aromatic hydrocarbons, amines, and carbon monoxide to prepare salicylanilides comprising the steps of:

(1) dehydrating and deoxidizing the catalyst and the reaction substrate

, sealed and standby.

(2) Treatment of reaction atmosphere

The reactor in step (1) will be ultrasonic 15-30min, high-purity carbon monoxide will be flushed into the ball gallbladder standby, ultrasonic completed with a mechanical pump to replace the atmosphere in the reactor to carbon monoxide gas.

(3) The above-treated reactor was placed on a stirrer for 4-30 hours, and when the reaction was completed, the mixture was taken out in a ventilated kitchen, centrifuged, and the supernatant, which was a mixed solution containing the target product salicylanilide, was analyzed qualitatively and quantitatively by GC-MS and GC for the samples to be tested.

Salicylanilide(87-17-2)Related Product Information

• POLY(N-ISOPROPYL ACRYLAMIDE)
• N-Isopropylacrylamide
• Salicylamide
• Oxanilide
• Sodium salicylate
• N-Methylolacrylamide
• Sodium 4-aminosalicylate dihydrate
• Salicylhydrazide
• Salicylaldehyde
• Aniline
• N-Methylaniline
• Salicylaldoxime
• CHLOROPHOSPHONAZO III
• D-(-)-Salicin
• Benzyl salicylate
• Sancycline
• Salinomycin
• Methyl salicylate