7-Chloroindole Chemical Properties

Melting point:

55-58 °C(lit.)

Boiling point:

90-95 °C0.25 mm Hg(lit.)

Density 

1.1976 (rough estimate)

refractive index 

1.5660 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

15.42±0.30(Predicted)

color 

White to Light yellow to Dark green

BRN 

114743

InChI

InChI=1S/C8H6ClN/c9-7-3-1-2-6-4-5-10-8(6)7/h1-5,10H

InChIKey

WMYQAKANKREQLM-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2Cl)C=C1

CAS DataBase Reference

53924-05-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

7-Chloroindole Usage And Synthesis

Chemical Properties

Beige-yellowish powder

Uses

7-Chloroindole may be used in the preparation of 1-methyl-7-chloroindole and glycosylated 7-chloroindole-3-acetamide.

General Description

7-Chloroindole is an indole derivative. It has been synthesized from 2,3-dihydroindole.

Synthesis

3-Chloro-2-nitrotoluene (2 mmol) was dissolved in 20 mL of acetonitrile and DMFDMA (480 mg, 4 ) was added. DMFDMA (480 mg, 4 ) was added and refluxed at elevated temperature for 5 h. The reaction was monitored by TLC, cooled, concentrated under reduced pressure, and the residue was washed with water and a small amount of ethanol to give Intermediate 4. Intermediate 4 was added to 50 mL of 10% hydrazine in methanol. Intermediate 4 was added into 50mL of 10% hydrazine in methanol solution, warmed to 50??, and reacted for 8h, and the reaction was monitored by TLC . The reaction was completed, cooled to room temperature, concentrated under reduced pressure and purified by column chromatography (petroleum ether:ethyl acetate 20:1) to obtain the target compound. The product data were as follows: white solid, yield 57%.

7-Chloroindole(53924-05-3)Related Product Information

• Indometacin
• Indole-3-acetic acid
• Indoline
• Indole-3-butyric acid
• Indole
• 7-CHLORO-1H-INDAZOLE
• 7-CHLORO-1H-INDOLE-3-CARBOXYLIC ACID
• 7-chloroindolin-2-one
• 2-OXO-INDOLINE-7-CARBOXYLIC ACID
• 7-NITROOXINDOLE
• 7-Hydroxyindole
• 7-chloroindoline
• 1H-INDOL-7-OL,2,3-DIHYDRO
• 7-indolinecarbonitrile
• Ethyl 7-chloroindole-2-carboxylate
• 7-NITRO-2,3-DIHYDRO-1H-INDOLE
• 1H-INDOLE-7-CARBOXYLIC ACID,2,3-DIHYDRO-
• 7-CYANOOXINDOLE