D-Phenylalanine, N-[[4-(1-methylethyl)cyclohexyl]carbonyl]-, cis- Chemical Properties

Boiling point:

527.6±39.0 °C(Predicted)

Density 

1.104±0.06 g/cm3(Predicted)

pka

3.61±0.10(Predicted)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

HS Code 

2924296000

D-Phenylalanine, N-[[4-(1-methylethyl)cyclohexyl]carbonyl]-, cis- Usage And Synthesis

Uses

N-[[cis-4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine, is an impurity of Nateglinide (N379375), which is an amino-acid derivative that stimulates insulin secretion, and used as an antidiabetic. Nateglinide USP Related Compound C.

Definition

ChEBI: Nateglinide is an N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-administered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus. It has a role as an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor and a hypoglycemic agent.