2-Pyridinecarboxamide,5-fluoro-(9CI) Chemical Properties

Boiling point:

272.9±25.0 °C(Predicted)

Density 

1.327±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

15.00±0.50(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

2-Pyridinecarboxamide,5-fluoro-(9CI) Usage And Synthesis

Synthesis

A solution of tetrahydrofuran (THF, 40 mL) of 5-fluoro-2-pyridinecarbonyl chloride (2.30 g, 14.4 mmol, 1.00 eq.) was slowly added dropwise to a stirred saturated ammonium hydroxide solution (40 mL) at 0 °C. The reaction mixture was stirred continuously at 10 °C for 30 min. Subsequently, the solvent was removed by distillation under reduced pressure. The residue was dissolved in dichloromethane (30 mL) and washed with saturated saline (2 x 30 mL). The organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give 1.82 g of 5-fluoro-2-pyridine carboxamide as a yellow solid in 71% yield. Mass spectrum (electrospray ionization, m/z): 140.9 ([M+H]+).

References

[1] Patent: WO2015/51479, 2015, A1. Location in patent: Page/Page column 65; 66
[2] Patent: WO2015/54038, 2015, A1. Location in patent: Page/Page column 57; 65; 66

2-Pyridinecarboxamide,5-fluoro-(9CI)(499796-71-3)Related Product Information

• Formamide
• 5-Fluoro-2-forMylpyridine
• 2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI)
• METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
• 3-FLUORO-5-FORMYLPYRIDINE
• 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
• 4-Pyridinecarboxamide,2-cyano-(9CI)