4-NITROPICOLINIC ACID Chemical Properties

Melting point:

153℃

Boiling point:

384.9±27.0 °C(Predicted)

Density 

1.570

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

2.88±0.10(Predicted)

color 

White to Orange to Green

CAS DataBase Reference

13509-19-8(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

29339900

4-NITROPICOLINIC ACID Usage And Synthesis

Chemical Properties

White solid

Synthesis

Synthesis of III-2-2:4-nitropyridine carboxylic acid 5.00 g (34 mmol) of 2-cyano-4-nitropyridine was dissolved in 50 g of 90% sulfuric acid and the reaction was stirred at 120°C for 2 hours. Subsequently, a solution of 5.60 g of sodium sulfite dissolved in 10 ml of water was slowly added dropwise at 20 °C to 25 °C, and the stirring was continued at the same temperature for 1 h. After that, the reaction was warmed up to 80 °C for 1 h. The reaction was completed by cooling to room temperature. Upon completion of the reaction, it was cooled to room temperature, diluted by adding 100 g of ice water, and the pH of the mixture was adjusted with sodium carbonate to about 2. The mixture was allowed to stand in a refrigerator to induce precipitation of solids. The precipitate was collected by filtration and recrystallized using a water-acetone solvent mixture to give 3.50 g of light yellow crystalline product in 62.1% yield. The melting point of the product was 157°-158°C (accompanied by decomposition).The IR (KBr) spectrum showed characteristic absorption peaks located at 1710, 1600, 1585, 1535 cm-1 .

References

[1] Journal of the American Chemical Society, 2012, vol. 134, # 47, p. 19366 - 19369
[2] Patent: US5219847, 1993, A
[3] Journal of Organometallic Chemistry, 1997, vol. 544, # 2, p. 163 - 174

4-NITROPICOLINIC ACID(13509-19-8)Related Product Information

• 5-NITROPICOLINIC ACID
• 2-Nitropyridine-4-carboxylic acid
• 6-NITROPICOLINIC ACID
• 6-Methyl-5-nitropicolinic acid
• 3-nitropicolinic acid
• 3-Nitroisonicotinic acid
• 5,6-Dimethyl-4-nitropicolinic acid
• 6-Methyl-4-nitropyridine-2-carboxylic acid
• SPECS AC-907/25005407
• 3-Methyl-4-nitropyridine-2-carboxylic acid
• CHEMPACIFIC 38132
• 4-Nitropicolinic acid 1-oxide
• 4-NITROPICOLINIC ACID