CAPTOPRIL DISULFIDE Chemical Properties

Melting point:

224-226°C

Boiling point:

714.8±60.0 °C(Predicted)

Density 

1.383±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated)

form 

Solid

pka

3.29±0.20(Predicted)

color 

White to Off-White

Safety Information

WGK Germany 

3

HS Code 

2933999552

CAPTOPRIL DISULFIDE Usage And Synthesis

Description

Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril . Captopril disulfide is the main degradation product of captopril and is formed by oxidation. It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID₅₀ = 0.231 mg/kg, i.v.).

Chemical Properties

White Solid

Uses

Captopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.

Definition

ChEBI: An organic disulfide in which the disulfide bond links two units of captopril. It is a secondary metabolite of captopril.

References

[1] T KOMAI. In vitro studies on the metabolic pathway of SQ 14225 (Captopril) and mechanism of mixed disulfide formation.[J]. Journal of pharmacobio-dynamics, 1981, 4 9: 677-684. DOI: 10.1248/bpb1978.4.677
[2] BENEDETTA PASQUINI . Cyclodextrin- and solvent-modified micellar electrokinetic chromatography for the determination of captopril, hydrochlorothiazide and their impurities: A Quality by Design approach[J]. Talanta, 2016, 160: Pages 332-339. DOI: 10.1016/j.talanta.2016.07.038
[3] N O’HARA  K H  H Ono. Potentiation of bradykinin-induced decrease of blood pressure in dogs by SO 14,551, the disulfide metabolite of captopril.[J]. Japanese journal of pharmacology, 1982, 32 5: 934-937. DOI: 10.1254/jjp.32.934

CAPTOPRIL DISULFIDE(64806-05-9)Related Product Information

• Ion pair reagent
• Captopril
• 1-[(2R)-3-Hydroxy-2-Methyl-1-oxopropyl]-L-proline
• Canagliflozin Dimer
• alpha-Capecitabine
• 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine
• CAPECITABINE related substance USP
• (2S)-1-[(2S)-2-Methyl-3-Methylsulfinylpropanoyl]pyrrolidine-2-carboxylic acid
• 5'-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2',3'-diacetate
• pentyl(1-((2R,3R,4R,5R)-3,4-bis(((2S,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)oxy)-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate
• 2'-O-(5'-Deoxy-β-D-ribofuranosyl) Capecitabine
• 5'-Deoxy-5-fluorocytidine
• 1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline
• (2S)-1-[2-Methylpropanoyl]-pyrrolidine-2-carboxylic Acid
• Captopril tablets
• DIISOBUTYL DISULFIDE
• CAPTOPRIL DISULFIDE
• CAPTOPRIL IMP. A (EP): CAPTOPRIL DISULPHIDE MM