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CAPTOPRIL DISULFIDE

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CAPTOPRIL DISULFIDE Basic information

Product Name:
CAPTOPRIL DISULFIDE
Synonyms:
  • CAPTOPRIL DISULFIDE
  • CAPTOPRIL DISULFIDE USP
  • CAPTOPRIL DISULFIDE USP(CRM STANDARD)
  • CAPTOPRIL DISULFIDE WHO(CRM STANDARD)
  • CAPTOPRIL DISULPHIDE BP STANDARD
  • Captopril ImpurityⅠ:Captopril Disulfide{ 1,1'-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline CAPTOPRDS}
  • Imp. A (EP):1,1'-[Disulfanediylbis-[(2S)-2-methyl-1-oxopropane-3,1-diyl]]-bis[(2S)-pyrrolidine-2-carboxylic] Acid(Captopril Disulfide)
  • Captopril Impurity A
CAS:
64806-05-9
MF:
C18H28N2O6S2
MW:
432.55
Product Categories:
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
64806-05-9.mol
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CAPTOPRIL DISULFIDE Chemical Properties

Melting point:
224-226°C
Boiling point:
714.8±60.0 °C(Predicted)
Density 
1.383±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated)
pka
3.29±0.20(Predicted)
color 
White to Off-White
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Safety Information

WGK Germany 
3
HS Code 
2933999552
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CAPTOPRIL DISULFIDE Usage And Synthesis

Description

Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril . Captopril disulfide is the main degradation product of captopril and is formed by oxidation. It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID50 = 0.231 mg/kg, i.v.).

Chemical Properties

White Solid

Uses

Captopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.

Definition

ChEBI: An organic disulfide in which the disulfide bond links two units of captopril. It is a secondary metabolite of captopril.

CAPTOPRIL DISULFIDESupplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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marketing_china@spectrumchemical.com
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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CAPTOPRIL DISULFIDE(64806-05-9)Related Product Information