(1'S,2'S)-NICOTINE 1'-OXIDE Chemical Properties

Melting point:

182-183°C

storage temp. 

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

solubility 

DMF: 50 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml

form 

A crystalline solid

pka

4.63±0.40(Predicted)

Stability:

Hygroscopic

(1'S,2'S)-NICOTINE 1'-OXIDE Usage And Synthesis

Chemical Properties

Off-White to Yellow Solid

Uses

Nicotine-1’-N-oxide is a derivative of Nicotine (N412420) found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1’-N-oxide has also been identified as a metabolite of nicotine in animals and in man. The metabolism of nicotine in man proceeds by alternative routes of oxidation of nitrogen to form nicotine-1’-N-oxide (both diastereomers) or cotinine. The ratio of these two products has been suggested as an indicator of bladder cancer in humans.

Uses

Nicotine-1’-N-oxide is a derivative of nicotine found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1’-N-oxide has also been identified as a metabolite of nicotine in animals and in man. The metabolism of nicotine

Definition

ChEBI: Trans-(S)-nicotine N(1')-oxide is an (S)-nicotine N(1')-oxide in which the N(1')-methyl group is on the opposite side of the pyrrolidine ring to the pyridine substituent. The major species at pH 7.3.

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