2-Methoxy-6-methylaminopyridine Chemical Properties

Boiling point:

156/759mm

Density 

1.01

refractive index 

1.4995

Flash point:

156°C

storage temp. 

Inert atmosphere,Room Temperature

form 

clear liquid

pka

4.12±0.10(Predicted)

color 

Colorless to Light yellow

Water Solubility 

Slightly soluble in water.

CAS DataBase Reference

63071-03-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/38-10

Safety Statements 

26-36/37/39-36/37-23-9

RIDADR 

1993

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29333990

2-Methoxy-6-methylaminopyridine Usage And Synthesis

Uses

2-Methoxy-6-methylpyridine is used as a pharmaceutical intermediate.

Synthesis

1) A mixture of 2-hydroxy-6-methylpyridine (164 g, 1.47 mol), iodomethane (1.35 kg, 9.53 mol) and Ag2CO3 (526 g, 1.91 mol) in THF (10 mL) was stirred at ambient temperature for 1 hr under light-avoiding conditions.2) Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the mixture was washed with THF The filter cake was washed with THF. 3) The filtrates were combined and concentrated in vacuum until complete removal of methyl iodide was confirmed by HPLC analysis to give 145.6 g of 2-methoxy-6-methylpyridine in 80% yield.

References

[1] Tetrahedron Letters, 1997, vol. 38, # 35, p. 6153 - 6156
[2] Synthetic Communications, 1994, vol. 24, # 10, p. 1367 - 1379
[3] Tetrahedron, 2000, vol. 56, # 20, p. 3181 - 3187
[4] Patent: US2006/287292, 2006, A1. Location in patent: Page/Page column 28
[5] Patent: US2007/281918, 2007, A1. Location in patent: Page/Page column 13

2-Methoxy-6-methylaminopyridine(63071-03-4)Related Product Information

• 2-Methoxypyridine
• 2,4,6-Collidine
• 2-Chloro-5-chloromethylpyridine
• 2,6-Lutidine
• 4-Methylpyridine
• (Trifluoromethoxy)benzene
• 2-Picoline
• Azamethiphos
• 2-Methoxy-4-methylpyridine
• 2-METHOXY-5-PICOLINE
• 5-Bromo-2-methoxy-6-picoline
• 2-Methoxy-5-(trifluoromethyl)pyridine
• 4-CHLORO-2-METHOXY-PYRIDINE
• 2-METHOXY-5-NITRO-6-PICOLINE
• 5-Chloro-2-methoxypyridine
• 5-Bromo-2-methoxypyridine
• 2-Methoxy-5-nitropyridine
• 4-Amino-2-methoxypyridine