kaurenoic acid Chemical Properties

Melting point:

171-172 °C

Boiling point:

426.6±34.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 10 mg/ml

form 

A solid

pka

4.70±0.40(Predicted)

color 

White to off-white

Safety Information

WGK Germany 

3

kaurenoic acid Usage And Synthesis

Description

Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties. It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC₅₀ values ranging from 15.03 to 48.87 μg/ml. Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml). Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.

Uses

ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma.

Definition

ChEBI: An ent-kaurane diterpenoid that is ent-kauran-19-oic acid in which a double bond is present at position 16(17); exhibits anticancer and anti-HIV 1 activity.

kaurenoic acid(6730-83-2)Related Product Information

• ISOEGOMAKETONE
• Deacetyltaxol
• Continentalic acid
• Carboxyatractyloside
• DARUTOSIDE
• 10-Deacetylbaccatin III
• dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate
• DARUTIGENOL
• β-Elemonic Acid
• ISOBAVACHALCONE
• RUBUSOSIDE
• Rebaudioside A
• Steviol
• wedeloside
• glucosilsteviol
• Rebaudioside D
• kaurenoic acid
• STEVIOL METHYL ESTER