Estradiol benzoate Chemical Properties

Melting point:

191-198 °C(lit.)

alpha 

D25 +58 to +63° (c = 2 in dioxane)

Boiling point:

465.03°C (rough estimate)

Density 

1.0493 (rough estimate)

refractive index 

1.5460 (estimate)

storage temp. 

2-8°C

solubility 

Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in methanol.

pka

15.06±0.40(Predicted)

form 

Solid

color 

White

Water Solubility 

0.4mg/L(25 ºC)

Merck 

3703

BRN 

3107526

CAS DataBase Reference

50-50-0(CAS DataBase Reference)

NIST Chemistry Reference

Estradiol benzoate(50-50-0)

Safety Information

Hazard Codes 

T

Risk Statements 

60-61-40

Safety Statements 

53-22-36/37/39-45

WGK Germany 

3

RTECS 

KG4050000

F 

8

HS Code 

29372319

MSDS

• Language:English Provider:1,3,5(10)-Estratriene-3,17b-diol 3-benzoate
• Language:English Provider:SigmaAldrich

Estradiol benzoate Usage And Synthesis

Chemical Properties

White solid

Uses

antiacne, antineoplastic

Uses

Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the treatment of lesions produced by diminution of bodily production of estrogens.

Definition

ChEBI: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.

Clinical Use

Estradiol is a semisynthetic estrogen compound. Its effects will mimic that of estrogen in animals. The most common use in small animals has been to terminate pregnancy.
Estradiol benzoate also has been used to terminate pregnancy (5-10 mg/kg divided into two or three SQ injections). Estradiol cypionate formulation had high efficacy (95%), but it had serious adverse effects and is not recommended. Estradiol cypionate is longer acting and more potent than other estrogen formulations. Estradiol valerate injection (20 mg/mL) is also available for human medicine to treat hypoestrogenism.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human reproductive effects by intramuscular route: menstrual cycle changes and disorders. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.

Estradiol benzoate(50-50-0)Related Product Information

• Emamectin benzoate
• Denatonium Benzoate Anhydrous
• Methylparaben
• Sodium benzoate
• Estradiol valerate
• Butylparaben
• Isopropylparaben
• Oestradiol 17-heptanoate
• Salicylic acid
• 2'-Hydroxy-3-phenylpropiophenone
• 3-Hydroxybenzoic acid
• 4-Hydroxybenzoic acid
• Estradiol
• Benzoic acid
• Benzyl benzoate
• Estradiol-3-benzoate-17-butyrate
• RIFAMPICIN N-OXIDE
• Rifampicin