Basic information Safety Supplier Related

pivalyloxymethyl butyrate

Basic information Safety Supplier Related

pivalyloxymethyl butyrate Basic information

Product Name:
pivalyloxymethyl butyrate
Synonyms:
  • pivalyloxymethyl butyrate
  • ((2,2-Dimethylpropanoyl)oxy)methyl butanoate
  • Brn 4861411
  • Butanoic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester
  • Pivanex
  • Chronic,leukemia,AN 9,muscular,Acute,ALL,atrophy,Inhibitor,lung,Histone deacetylases,NSCLC,myelogenous,lymphoblastic,cancer,HDAC,AN9,CML,Pivanex,spinal,K562,Apoptosis,inhibit,Bcr-Abl
  • Pivanex, 10 mM in DMSO
CAS:
122110-53-6
MF:
C10H18O4
MW:
202.25
Mol File:
122110-53-6.mol
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pivalyloxymethyl butyrate Chemical Properties

Boiling point:
249.3±13.0 °C(Predicted)
Density 
1.008±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: ≥10mg/mL
form 
oil
color 
colorless or slightly yellow
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Safety Information

WGK Germany 
nwg
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pivalyloxymethyl butyrate Usage And Synthesis

Uses

AN-9 is an HDAC inhibitor with antimetastic and antiangiogenic properties. Histone deacetylase inhibitors in cancer therapy. Formaldehyde-releasing prodrugs for localized anticancer chemotherapy.

in vivo

Pivanex (AN9, 200 mg/kg, b.i.d, daily) significantly improves the survival of SMN7 SMA mice. Pivanex (AN9) treatment also marked delays the end stage of disease as defined by the onset of body mass loss[3].

Animal Model:SMN7 SMA mice (SMN2+/+; SMN7+/+; mSmn?/?)[3].
Dosage:200 mg/kg.
Administration:Oral administration, b.i.d, at 09.00 and 17.00 daily.
Result:Improved the mean lifespan of treated SMN7 SMA mice by 84.6%.
Delayed the onset of body mass loss in SMN7 SMA mice by 94.9%.

IC 50

HDAC; Bcr-Abl

pivalyloxymethyl butyrateSupplier

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