chikusetsu saponin IVa Chemical Properties

Melting point:

218-220℃ (methanol , water )

Boiling point:

873.3±65.0 °C(Predicted)

Density 

1.37±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

2-8°C

solubility 

DMSO : 100 mg/mL (125.79 mM; Need ultrasonic)

form 

powder

pka

2.82±0.70(Predicted)

color 

White-off-white

InChIKey

YOSRLTNUOCHBEA-SGVKAIFKSA-N

Safety Information

Safety Statements 

24/25

HS Code 

29389090

chikusetsu saponin IVa Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Panax notoginseng.

Uses

Chikusetsusaponin Iva is the main active component of triterpenoid saponins, acts as an activator of protein kinases, and has a resistance effect against thrombosis and some metabolic diseases.

Definition

ChEBI: A natural product found in Panax japonicus var. major.

References

[1] Wang H, et al.Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells. Int J Immunopathol Pharmacol. 2015 Jul 8. DOI:10.1177/0394632015589519
[2] Cui J, et al. Insulinotropic effect of Chikusetsu saponin IVa in diabetic rats and pancreatic β-cells. J Ethnopharmacol. 2015 Apr 22;164:334-9. DOI:10.1016/j.jep.2015.02.032
[3] Li Y, et al. Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects. J Pharm Pharmacol. 2015 Jul;67(7):997-1007. DOI:10.1111/jphp.12392
[4] Dahmer T, et al. Antithrombotic effect of chikusetsusaponin IVa isolated from Ilex paraguariensis (Maté). J Med Food. 2012 Dec;15(12):1073-80. DOI:10.1089/jmf.2011.0320

chikusetsu saponin IVa(51415-02-2)Related Product Information

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• Terrestrosin K
• dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate
• Pachymic acid
• ALLEOSIDE A
• Madecassoside
• Carboxyatractyloside
• Madecassic acid
• Terrestrosin D
• Poricoic acid A(F)
• roburic acid
• (1S)-1,2,3,3a,5aβ,6,10b,10cβ-Octahydro-1,2α,6α-trihydroxy-3aβ,10bα-dimethyl-7-isopropyl-4H,9H-furo[2',3',4':4,5]naphtho[2,1-c]pyran-4,9-dione
• podocarpusflavone A
• HYPOCRELLIN A
• Ginsengrootextract
• 20(R)-Ginsenoside Rg3
• Saponin