6-aminocarbovir Chemical Properties

Melting point:

180-182°C

Boiling point:

628.2±65.0 °C(Predicted)

Density 

1.75±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

pka

14.86±0.10(Predicted)

color 

Off-White to Pale Yellow

Safety Information

Hazard Codes 

Xi

Risk Statements 

41-43

Safety Statements 

26-36/37-39

HS Code 

2933599550

6-aminocarbovir Usage And Synthesis

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Uses

Abacavir Intermediate.

6-aminocarbovir(124752-25-6)Related Product Information

• Abacavir
• Abacavir Carboxylate
• Abacavir sulfate
• (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol
• 2,6-Diaminopurine
• Abacavir
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)-
• Abacavir Related CoMpound D
• (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
• Abacavir
• (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride
• Abacavir-d4
• Abacavir 5’-Phosphate
• 2-Amino-6-cyclopropylamino-9H-purine
• Abacavir 5'-Glucuronide
• Abacavir
• trans-Abacavir Hydrochloride
• Abacavir Impurity 1