epsilon-viniferin Chemical Properties

Melting point:

approximate 157℃ (dec.)

storage temp. 

Store at -20°C

solubility 

Soluble in methanol;

form 

Powder

color 

Off-white to gray

Water Solubility 

sparingly soluble in water

LogP

3.802 (est)

epsilon-viniferin Usage And Synthesis

Description

trans-ε-Viniferin is a stilbene polyphenol and dimer of trans-resveratrol that has been found in various red wines and has diverse biological activities. It induces disaggregation of aggregated amyloid-β (1-42) (Aβ42; ) fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures. trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells (EC₅₀ = 30 nM). It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt. trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells (IC₅₀ = ~1 μM). In vivo, trans-ε-viniferin (2 μg per animal) reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity.

Uses

ε-Viniferin is a stilbene extract posessing cytotoxic effects and may contain anti-cancer properties.

Definition

ChEBI: (-)-trans-epsilon-viniferin is a stilbenoid that is the (-)-trans-stereoisomer of epsilon-viniferin, obtained by cyclodimerisation of trans-resveratrol. It has a role as a metabolite. It is a member of 1-benzofurans, a polyphenol and a stilbenoid. It is functionally related to a trans-resveratrol. It is an enantiomer of a (+)-trans-epsilon-viniferin.

target

5-HT Receptor | MAO | Antifection

epsilon-viniferin(62218-08-0)Related Product Information

• 2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)-
• PICEATANNOL
• 3,4',5-TRIMETHOXY-TRANS-STILBENE
• Resveratrol
• TRANS-RESVERATROL 4'-O-BETA-D-GLUCURONIDE
• Resveratrol-4'-O-(6"-galloyl)-b-d-glucopyranoside
• Salvianolicacid C
• Rhapontigenin 3'-O-glucoside
• Salvianolic acid
• TRANS-ASTRINGIN