2-bromolysergic acid diethylamide Chemical Properties

Melting point:

120-127°

alpha 

D20 +15° (c = 0.5 in pyridine); D20 +53° (c = 0.5 in chloroform)

Density 

1.3040 (rough estimate)

refractive index 

1.6770 (estimate)

solubility 

DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml

form 

Solid

Boiling point:

580.7±50.0 °C(Predicted)

pka

15.65±0.40(Predicted)

color 

Off-white to light yellow

2-bromolysergic acid diethylamide Usage And Synthesis

Uses

2-Bromo-LSD (BOL-148; Bromolysergide) is a Dopamine Receptor antagonist that directly affects dopamine neurons in the substantia nigra neostriatum. 2-Bromo-LSD increases the hydroxylation of tyrosine in striatum and antagonizes the decrease of Apomorphine-induced DOPA accumulation. 2-Bromo-LSD also blocks the 5-HT Receptor mediated DOPA formation[1].

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: ddation of the arteries or veins. Many lysergic acid derivatives have central nervous system effects. When heated to decomposition it emits very toxic fumes such as Brand NOx. See other lysergic acid derivatives.

in vivo

References

[1] Persson SA. The effect of LSD and 2-bromo LSD on the striatal DOPA accumulation after decarboxylase inhibition in rats. Eur J Pharmacol. 1977 May 1;43(1):73-83. DOI:10.1016/0014-2999(77)90162-5
[2] PAUL CARVEY . LSD and other related hallucinogens elicit myoclonic jumping behavior in the guinea pig[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 1989, 13 1: Pages 199-210. DOI: 10.1016/0278-5846(89)90017-1
[3] WACHEŁKO O, NOWAK K, TUSIEWICZ K, et al. A highly sensitive UHPLC-MS/MS method for determining 15 designer LSD analogs in biological samples with application to stability studies†[J]. Analyst, 2024, 2: 290-308. DOI: 10.1039/d4an01361a

2-bromolysergic acid diethylamide(478-84-2)Related Product Information

• Lysergic acid diethylamide