D-Trp(34) neuropeptide Y Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble to 0.20 mg/ml in 20% acetonitrile

form 

Powder

color 

White to off-white

D-Trp(34) neuropeptide Y Usage And Synthesis

Uses

[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats[1][2].

in vivo

IC 50

NPY Y₅ receptor

References

[1] E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9. DOI:10.1016/s0196-9781(00)00156-x
[2] Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4. DOI:10.1080/10284150701676222

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