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Guan-fu base A

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Guan-fu base A Basic information

Product Name:
Guan-fu base A
Synonyms:
  • Guan-fu base A
  • (2α,11α,13R)-Hetisan-2,11,13,14-tetrol 2,11-diacetate
  • (2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate
  • Acehytisine
  • Kwan-fu base A
  • Hetisan-2,11,13,14-tetrol, 2,13-diacetate, (2α,11α,13R)-
  • Hetisan-2,11,13,14-tetrol,2,13-diacetate, (2a,11a,13R)-
  • Guan-fu base A USP/EP/BP
CAS:
1394-48-5
MF:
C24H31NO6
MW:
429.51
Mol File:
1394-48-5.mol
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Guan-fu base A Chemical Properties

Boiling point:
541.5±50.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
4°C, away from moisture and light
pka
12.97±0.70(Predicted)
form 
Solid
color 
White to off-white
InChIKey
OGNUSOJAYIHLNS-UFZRWAKRNA-N
SMILES
O[C@]12[C@@H]([C@]3([H])C(=C)CC41C[C@@]1([H])[C@]5([H])[C@]6(C[C@H](OC(=O)C)C[C@]5([C@]4([H])[C@@H]3O)C2N1C6)C)OC(=O)C |&1:1,2,3,10,12,14,16,22,23,25,r|
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Guan-fu base A Usage And Synthesis

Chemical Properties

White crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the tuberous root of Aconitum carmichaelii (Kanbaifu), a plant of the Ranunculaceae family.

Uses

Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2].

in vivo

Beagle dogs treated intravenously with Dextromethorphan (2 mg/mL) after pretreatment with Guanfu base A injection shows reduced CYP2D metabolic activity, with the Cmax of dextrorphan being one-third that of the saline-treated group and area under the plasma concentration-time curve half that of the saline-treated group[1].

References

[1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380

Guan-fu base ASupplier

Huzhou ZhanShu Biotechnology Co.,Ltd Gold
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0572-8889530 18167260939
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zsubio@163.com
Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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cwb1@biopurify.cn
Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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tauto@tautobiotech.com
Chengdu Herbpurify Co.Ltd.
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2355253622; 18981954830
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2355253622@qq.com;
Wuxi Zhongkun Biochemical Technology Co., Ltd.
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0510-85629785 18013409632
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sales@reading-chemicals.com
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