tripterifordin Chemical Properties

Boiling point:

485.1±45.0 °C(Predicted)

Density 

1.19±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

15.24±0.40(Predicted)

InChI

InChI=1/C20H30O3/c1-17-7-3-8-20(12-23-16(17)21)14(17)6-9-19-10-13(4-5-15(19)20)18(2,22)11-19/h13-15,22H,3-12H2,1-2H3/t13-,14-,15+,17+,18-,19+,20+/s3

InChIKey

KLMZPLYXGZZBCX-VDOIHNSCNA-N

SMILES

[C@H]12CC[C@H]3[C@@](O)(C)C[C@]1(CC[C@@H]1[C@]4(C)CCC[C@@]21COC4=O)C3 |&1:0,3,4,8,11,12,17,r|

tripterifordin Usage And Synthesis

Uses

Tripterifordin possesses significant anti-HIV replication activities in H9 lymphocyte cells with an EC50?value of 3100 nM, respectively[1].

Definition

ChEBI: A kaurane diterpenoid that is (5beta,8alpha,13alpha)-18,20-epoxykauran-18-one substituted by a hydroxy group at position 16. Isolated from the roots of Tripterygium wilfordii, it exhibits anti HIV activity.

target

HIV | Immunology & Inflammation related

References

[1] Kobayashi S,?et al. Syntheses?of (-)-Tripterifordin?and (-)-Neotripterifordin?from?Stevioside.J Org Chem.?2018 Feb 2;83(3):1606-1613. DOI:10.1021/acs.joc.7b02916

tripterifordin(139122-81-9)Related Product Information

• Tripterygium glycosides
• WILFORINE
• Triptonide
• wilfortrine
• WILFORLIDE A
• TRIPTOPHENOLIDE
• demethylzeylasteral
• WILFORDINE
• Triptolide
• Celastrol
• ABITOL
• 4-ETHYL-4-BUTYL-DELTA-VALEROLACTONE
• 2H-Pyran-2-one, 3-ethyltetrahydro-
• 3,3-DIMETHYL-TETRAHYDRO-PYRAN-2-ONE
• tripterifordin
• 2,2,4-TRIMETHYLPENTYLMONOISOBUTYRATE
• 2H-Pyran-2-one, 3-ethyltetrahydro-, (S)-