Levocetirizine dihydrochloride Chemical Properties

Melting point:

215-220°C

alpha 

D25 -12.79° (c = 1 in water)

storage temp. 

room temp

solubility 

H2O: ≥23mg/mL

form 

powder

color 

White to Almost white

Merck 

14,2022

Stability:

Hygroscopic

CAS DataBase Reference

130018-87-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50/53

Safety Statements 

60-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

RTECS 

AG0990000

HS Code 

29335990

Levocetirizine dihydrochloride Usage And Synthesis

Uses

Anti Histaminic

Uses

Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.

General Description

Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is awhite, crystalline powder and is water soluble. ThisR-enantiomer is has a 30-fold higher affinity than the S-enantiomer,and dissociates more slowly from H₁-receptors.Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same therapeutic advantages. Levocetirizine isindicated for the relief of symptoms associated with allergicrhinitis (seasonal and perennial) in adults and children 6 yearsof age and older and for the treatment of the uncomplicatedskin manifestations of chronic idiopathic urticaria in adultsand children 6 years of age and older. Its pharmacokineticsand clearance profile are essentially the same as the racemate,cetirizine .

Biochem/physiol Actions

Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.

Levocetirizine dihydrochloride(130018-87-0)Related Product Information

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