CI 972 Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

CI 972 Usage And Synthesis

Uses

CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2].

in vivo

References

[1] Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. DOI:10.1007/978-1-4899-2638-8_8
[2] Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8. DOI:10.1016/0006-291x(91)91042-b

CI 972(115787-68-3)Related Product Information

• 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)
• 1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE
• 9-deaza-9-(3-thienylmethyl)guanine
• CI 972