5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Chemical Properties

Melting point:

207-208 °C

Boiling point:

513.7±50.0 °C(Predicted)

Density 

1.20±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

solubility 

DMSO: soluble5mg/mL, clear (warmed)

form 

powder

pka

4.86±0.42(Predicted)

color 

white to beige

Safety Information

Hazard Codes 

T,N

Risk Statements 

25-50/53

Safety Statements 

45-60-61

RIDADR 

UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

WGK Germany 

3

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Usage And Synthesis

Uses

L-152,804 is a potent and orally available Y5 antagonist, which is the receptor postulated to be responsible for hypothalamic "feeding".

Definition

ChEBI: 2-(3,3-dimethyl-1-oxo-4,9-dihydro-2H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione is a member of xanthenes.

Biological Activity

Potent, selective non-peptide neuropeptide Y Y 5 receptor antagonist (K i = 26 nM for hY 5 ). Displays > 300-fold selectivity over hY 1 , hY 2 , and hY 4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo .

storage

Desiccate at +4°C

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE(6508-43-6)Related Product Information

• Dimedone
• 3-N-PENTYL-2,4-PENTANEDIONE
• 2-Methyl-1,3-cyclohexanedione
• 3-N-BUTYL-2,4-PENTANEDIONE
• 2-BENZYLCYCLOHEXANONE
• 2-ALLYLCYCLOHEXANE-1,3-DIONE
• 2,4-Pentandedione, 3-(phenylmethyl)
• 3-(1-PHENYL-ETHYL)-PENTANE-2,4-DIONE
• 3-BENZYL-4-HEPTANONE
• (+)-MENTHONE
• 3-acetylheptane-2,6-dione
• 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE
• 1-METHOXY-5-METHYL-HEX-1-EN-3-ONE
• 2,5-DIMETHYLCYCLOHEXANE-1,3-DIONE
• 6-PHENOXY-HEXAN-2-ONE
• 5,5-dimethyl-2-prop-2-enyl-cyclohexane-1,3-dione
• 3-METHYLENE-2,6-HEPTANEDIONE, TECH. 85