Methotrexate disodium salt
Methotrexate disodium salt Basic information
- Product Name:
- Methotrexate disodium salt
- Synonyms:
-
- Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
- sodium methotrexate
- L-Glutamic acid, N-4-(2,4-diamino-6-pteridinyl)methylmethylaminobenzoyl-, disodium salt
- METHOTREXATUM
- 2-[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]aminopentanedioic acid
- (+)-N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt
- (+)-N-[4-[[(2,4-Diaminopteridine-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt
- 4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt
- CAS:
- 7413-34-5
- MF:
- C20H23N8NaO5
- MW:
- 478.44
- EINECS:
- 231-022-0
- Product Categories:
-
- Anti-cancer&immunity
- API
- Molecular biology Products
- Mol File:
- 7413-34-5.mol
Methotrexate disodium salt Chemical Properties
- Boiling point:
- 823℃
- RTECS
- MA1232000
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Water (Slightly)
- form
- Powder
- color
- Light yellow to yellow
- Water Solubility
- Soluble in water
- Sensitive
- Hygroscopic
- InChIKey
- MSDCZRQHAGWZSH-NVZXTOETNA-N
- SMILES
- NC1=NC(N)=NC2N=CC(CN(C3C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=3)C)=NC1=2.[NaH] |&1:19,r|
Methotrexate disodium salt Usage And Synthesis
Uses
Inhibits the metabolism of folic acid
Definition
ChEBI: Methotrexate disodium is an organic sodium salt that is the disodium salt of methotrexate. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It contains a methotrexate(2-).
Biological Activity
Methotrexate disodium salt is a potent is a folic acid antagonist th at is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase.
in vivo
Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4].
IC 50
Traditional Cytotoxic Agents
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