8-BENZYL-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONE Chemical Properties

Melting point:

259-261 °C

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

10.07±0.20(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C14H17N3O2/c18-12-14(16-13(19)15-12)6-8-17(9-7-14)10-11-4-2-1-3-5-11/h1-5H,6-10H2,(H2,15,16,18,19)

InChIKey

ISFXLJGTXHSNDU-UHFFFAOYSA-N

SMILES

N1C2(CCN(CC3=CC=CC=C3)CC2)C(=O)NC1=O

8-BENZYL-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONE Usage And Synthesis

Description

8-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione is a pharmaceutical intermediate compound that can be used to prepare biologically active compounds. Studies have shown that 1,3, 8-triazo [4.5] decane-2, 4-dione is a novel chemical type of agonist with DOR selectivity. δ -opioid receptors (DOR) are potential targets for the treatment of neurological and mental disorders. These agonists are similar to 1,3, 8-triazo [4.5] decane-4-one analogues and have been reported to be weakly selective NOR agonists with moderate binding affinity for DOR, MOR and KOR.

Uses

8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione is a useful research reagent used in the synthesis of spirohydantoins from basic heterocyclic ketones.

8-BENZYL-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONE(28936-94-9)Related Product Information

• 1,3,8-TRIAZA-SPIRO[4.5]DECANE-2,4-DIONE