Ropinirole Chemical Properties

Melting point:

243-250°C

Boiling point:

410.5±45.0 °C(Predicted)

Density 

1.040±0.06 g/cm3(Predicted)

pka

14.17±0.20(Predicted)

CAS DataBase Reference

91374-21-9(CAS DataBase Reference)

Safety Information

Hazardous Substances Data

91374-21-9(Hazardous Substances Data)

Ropinirole Usage And Synthesis

Uses

Antiparkinsonian (D2receptor agonist).

Definition

ChEBI: Ropinirole is a member of indolones and a tertiary amine. It has a role as a dopamine agonist, an antiparkinson drug, a central nervous system drug and an antidyskinesia agent.

brand name

Requip (GlaxoSmithKline).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 28, p. 1533, 1985 DOI: 10.1021/jm00148a028

Clinical Use

Anti-Parkinson agent
Restless legs syndrome (RLS)

Drug interactions

Potentially hazardous interactions with other drugs
Antipsychotics: antagonism of anti-Parkinsonian effect - avoid.
Metoclopramide: antagonism of anti-Parkinsonian effect - avoid.
Oestrogens: concentration increased.

Metabolism

Ropinirole is hepatically metabolised by the cytochrome P450 enzyme, CYP1A2, and excreted in the urine as inactive metabolites.

Ropinirole(91374-21-9)Related Product Information

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• ROPINIROLE HYDROCHLORIDE,ROPINIROLE HCL
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• DI-N-PROPYL-1,1,2,2,3,3,3-D7-AMINE (MONO-PROPYL-D7)
• Ropinirole