Basic information Safety Supplier Related

L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE

Basic information Safety Supplier Related

L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE Basic information

Product Name:
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
Synonyms:
  • L-Homocysteine thiolactone hydrochloride,L-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride
  • CAindexname:2(3H)-Thiophenone,3-aminodihydro-,hydr
  • (S)-3-Aminodihydro-2(3H)-thiophenone hydrochloride
  • L-HOMOCYSTEINE THIOLACTONE HCL*CRYST
  • -3-Aminodihydrothiophen-2(3H)
  • H-HOCYS-THIOLACTONE HCL
  • 2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, (3S)-
  • 2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, L-
CAS:
31828-68-9
MF:
C4H8ClNOS
MW:
153.63
EINECS:
250-824-1
Mol File:
31828-68-9.mol
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L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE Chemical Properties

Melting point:
185-191 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)
form 
Solid
color 
Pale Beige
BRN 
3911455
Stability:
Hygroscopic
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
F 
1-8-9

MSDS

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L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

Colourless solid

Uses

L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors.

Biochem/physiol Actions

L-Homocysteine thiolactone, an amine reactive agent, is used to study post-translational modification of proteins, especially at lysine residues.

in vivo

L-Homocysteine thiolactone hydrochloride can be used to create models of hyperhomocysteinemia[2].

Induction of Hyperhomocysteinemia (HHcy)[2][3]
Background
Homocysteine (Hcy) is an amino acid that requires vitamins B12 and folic acid for its metabolism. Vitamins B12 and folic acid deficiencies lead to hyperhomocysteinemia (HHcy, elevated Hcy), which is linked to the development of diabetic retinopathy (DR), age-related macular degeneration (AMD), and Alzheimer’s disease (AD).
Specific Modeling Methods
Male C57Mice: cbs+/-; 3-5 weeks ? C57BL6/J; 6-8 weeks of age
Administration: 1 μL ? intravitreally ? 200 μM BL/6 mice (5 weeks old)
Note
(1) To avoid uncontrolled intraocular pressure increase, the volume of intravitreal injections is limited to 1 μL.
(2) L-Homocysteine thiolactone hydrochloride is dissolved in water and a working solution of 10x is prepared by diluting 1 μL of stock solution (200 mM) to 100 μL with PBS. Then by injecting 1 μL of this working solution, 200 μM vitreal concentration of Hcy-thiolactone is obtained.
Modeling Indicators
Molecular changes: Caused microglia activation in the retina. Increased indicators: pro-inflammatory cytokines IP-10, TNFα, IL-1β, and IL6
Correlated Product(s): L-Homocysteine (HY-W010347)
Opposite Product(s): /

Animal Model:cbs+/- mice and normal wild type mice (C57BL6/J), 6-8 weeks of age[2]
Dosage:1 μL; 200 μM
Administration:Intravitreally
Result:Normal retinal flat-mount preparations from cbs+/+ mice showed quiescent ramified microglia, while cbs-/- and cbs+/- retinas demonstrated rod-like microglia devoid of branching processes, indicating microglia activation in HHcy mice.

L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDESupplier

China DongFan Chemical Co.,LTD
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86-0571-85151182
Syntechem Co.,Ltd
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Email
info@syntechem.com
China Langchem Inc.
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0086-21-58956006
Tianjin heowns Biochemical Technology Co., Ltd.
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400 638 7771
Email
sales@heowns.com
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Email
sj_scrc@sinopharm.com
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L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE(31828-68-9)Related Product Information