6 beta-hydroxycortisol Chemical Properties

Melting point:

182-190?C

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Pale Yellow

6 beta-hydroxycortisol Usage And Synthesis

Chemical Properties

Off-White to Pale Yellow Solid

Uses

A metabolite of Cortisol

Definition

ChEBI: 6beta-hydroxycortisol is a C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. It has a role as a mammalian metabolite, a human metabolite and a probe. It is a C21-steroid, a 6beta-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 21-hydroxy steroid, a 20-oxo steroid, a 17alpha-hydroxy steroid, an 11beta-hydroxy steroid, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It is functionally related to a cortisol.

6 beta-hydroxycortisol(53-35-0)Related Product Information

• Dexamethasone-17-acetate
• Dexamethasone
• 9beta,11beta-epoxy-17,21-dihydroxypregn-4-ene-3,20-dione
• 11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE
• 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 17-acetate
• 6-Dehydrocortisol
• Hydrocortisone-17-butyrate