Basic information Safety Supplier Related

Timentin

Basic information Safety Supplier Related

Timentin Basic information

Product Name:
Timentin
Synonyms:
  • ticarcillin-clavulanic acid
  • (2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid:(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • (2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • TIMENTIN
  • TIMENTIN
  • TIMENTIN
  • TIMENTIN
  • Temetine
CAS:
86482-18-0
MF:
C15H16N2O6S2.C8H9NO5
MW:
583.593
Mol File:
86482-18-0.mol
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Timentin Chemical Properties

form 
Solid
color 
White to light yellow
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Timentin Usage And Synthesis

Antimicrobial activity

Activity is that of ticarcillin , the role of the inhibitor being to restore the activity against β-lactamase-producing strains that would otherwise hydrolyze the drug.

Pharmacokinetics

Cmax 3 g ticarcillin + 100 mg: 330 mg/L end: 8 mg/L end
clavulanate intravenous: infusion: infusion
infusion (30 min)
Plasma half-life: 1.1 h 1.1 h
Plasma protein binding: 45% 25%
The pharmacokinetics of the two agents are mutually unaffected by co-administration. Ticarcillin can be detected in tissues and interstitial fluid following parenteral administration. Penetration into bile, peritoneal fluid and pleural fluid has been demonstrated. Concentrations in blister fluid were significantly lower than those in serum.
Around 60–70% of ticarcillin and 35–45% of clavulanic acid are excreted unchanged in urine during the first 6 h after administration of a single dose of the mixture.

Clinical Use

Septicemia, including bacteremia
Lower respiratory infections
Bone and joint infections
Skin and skin structure infections
Urinary tract infections (complicated and uncomplicated)
Gynecological infections, endometritis
Intra-abdominal infections, peritonitis
Its main use is in infections in which Ps. aeruginosa is suspected or proven.

Side effects

Adverse reactions associated with ticarcillin occur . As with co-amoxiclav, there is a risk of cholestatic jaundice . Pseudomembranous colitis has been reported.

TimentinSupplier

AILY INTL CHEMICAL CORP LTD Gold
Tel
025-83208295 18913388297
Email
ben@ailychem.com
Hubei wei shi reagent group ltd., company Gold
Tel
027-59102966 18717199209
Email
2853877583@QQ.com
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Email
chenyj@titansci.com
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Email
shenlinxing@macklin.cn
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Email
xg01_gj@163.com