chloramphenicol 3-acetate Chemical Properties

Melting point:

89-91oC

Boiling point:

589.0±50.0 °C(Predicted)

Density 

1.473±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

10.85±0.46(Predicted)

form 

Solid

color 

White to Off-White

chloramphenicol 3-acetate Usage And Synthesis

Description

Chloramphenicol acetate is an acetylated and inactive version of chloramphenicol. It is formed in E. coli and S. aureus by the inducible enzyme chloramphenicol acetyltransferase in the presence of acetyl coenzyme A (acetyl-CoA; ) to confer chloramphenicol resistance. Chloramphenicol acetate has no antibiotic activity against S. sonnei in a turbidimetric assay.

Uses

Chloramphenicol acetate is a naturally-occurring co-metabolite of chloramphenicol in Streptomyces venezuelae with albeit significantly lower potency. Chloramphenicol acetate is the major product of chloramphenicol acetyltransferase, the major resistance mechanism to chloramphenicol.

Uses

Chloramphenicol 3-Acetate is an Chloramphenicol (C325030) derivative found in metabolic decomposition of Chloramphenicol by Alcaligenes faecalis.

Definition

ChEBI: Chloramphenicol 3-acetate is an acetate ester. It is functionally related to a chloramphenicol.

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