ginsenoside Rh(4)
ginsenoside Rh(4) Basic information
- Product Name:
- ginsenoside Rh(4)
- Synonyms:
-
- ginsenoside Rh(4)
- (3beta,6alpha,12beta,20E)-3,12-Dihydroxydammara-20(22),24-dien-6-yl-beta-D-glucopyranoside
- Ginsenoside Rh4, BR
- β-D-Glucopyranoside, (3β,6α,12β,20E)-3,12-dihydroxydammara-20(22),24-dien-6-yl
- ginsenoside Rh(4) USP/EP/BP
- (3β,6α,12β,20E)-3,12-Dihydroxydammara-20(22),24-dien-6-yl β-D-glu copyranoside
- Ginsenoside Rh4, 10 mM in DMSO
- Ginsenoside Rh4 ，E0769
- CAS:
- 174721-08-5
- MF:
- C36H60O8
- MW:
- 620.86
- Mol File:
- 174721-08-5.mol
ginsenoside Rh(4) Chemical Properties
- Melting point:
- >200°C (dec.)
- Boiling point:
- 723.4±60.0 °C(Predicted)
- Density
- 1.21
- storage temp.
- -20°C Freezer
- solubility
- Methanol (Slightly), Pyridine (Slightly)
- pka
- 12.91±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
ginsenoside Rh(4) Usage And Synthesis
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginseng.
Uses
Ginsenoside Rh4 possesses inhibitory and antifungal activity.
Definition
ChEBI: Ginsenoside Rh4 is a triterpenoid saponin.
in vivo
To assess whether Ginsenoside Rh4 can inhibit the growth of colorectal cancer, a colorectal cancer xenograft model is established by inoculating nude mice with Caco-2 cells. Mice treated with 20 and 40 mg/kg Ginsenoside Rh4 and 40 mg/kg CAMPTO exhibit smaller tumors than the control after 30 days of treatment, showing inhibition rates of 29.91%, 66.30% and 77.82%, respectively. However, there is a significant difference in body weight between the Ginsenoside Rh4-treated group and the CAMPTO-treated group. The body weights of the 20 and 40 mg/kg Ginsenoside Rh4-treated groups (15.95±0.35 g and 18.35±0.44 g) are markedly higher, whereas the body weight of the CAMPTO-treated group is lower (10.85±0.28 g) than that of the solvent control group (14.19±0.25 g)[1].
target
Caspase | Autophagy | Bcl-2/Bax
IC 50
Bax; Caspase 3; Caspase 8; Caspase 9; Apoptosis; Autophagy
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ginsenoside Rh(4)(174721-08-5)Related Product Information
- Ginsengrootextract
- 20(R)-Ginsenoside Rg3
- Ginsenoside Rh2
- Ginsenoside Rg3
- Ginsenoside Rd
- Ginsenoside Rk3
- Ginsenoside Rb3
- Ginsenoside Rh1
- Ginsenoside-Rg5
- PROTOPANAXTRIOL
- (3beta,12beta)-20-(beta-D-Glucopyranosyloxy)-12-hydroxydammara-5,24-dien-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
- (R) -ginsenoside Rh1
- Isoliquiritigenin
- 18β-Glycyrrhetinic Acid
- 23-O-β-D-glucopyranosyl-3β,12β,25-trihydroxyl daMMar-(E)-20(22)-ene
- Ginsenoside Rd2
- 20R-Ginsenoside Rh2
- Pseudoginsenoside RT5