(melle-4)cyclosporin Chemical Properties

Boiling point:

1293.6±65.0 °C(Predicted)

Density 

1.018±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 100 mg/mL (83.15 mM);Water : < 0.1 mg/mL (insoluble)

form 

Solid

pka

13.32±0.70(Predicted)

color 

White to off-white

(melle-4)cyclosporin Usage And Synthesis

Uses

NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) [1][2].

in vivo

References

[1] Ma S, et al. NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha IFN. Antimicrob Agents Chemother. 2006 Sep;50(9):2976-82. DOI:10.1128/AAC.00310-06
[2] Waldmeier PC, et al. Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol. 2002 Jul;62(1):22-9. DOI:10.1124/mol.62.1.22
[3] Rehman H, et al. NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liverregeneration after massive hepatectomy. Transplantation. 2011 Feb 27;91(4):406-12. DOI:10.1097/TP.0b013e318204bdb2