QUERCETINPENTAACETATE Chemical Properties

Melting point:

193 °C

Boiling point:

666.4±55.0 °C(Predicted)

Density 

1.45±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Dichloromethane, Ethyl Acetate

form 

Solid

color 

Beige

QUERCETINPENTAACETATE Usage And Synthesis

Description

Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in vitro (IC₅₀ = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC₅₀ = 20.2 μg/ml). Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC₅₀ = 8.7 μM) and PGE₂ production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM. It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC₅₀s = 38, 25, and 58 μM, respectively).

Uses

[5,7-Diacetyloxy-2-(3,4-diacetyloxyphenyl)-4-oxochromen-3-yl] Acetate is an intermediate in the synthesis of Quercetin Dihydrate (Q509500), which is a lavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle.

QUERCETINPENTAACETATE(1064-06-8)Related Product Information

• 7-METHOXYFLAVONOL
• Isorhamnetin
• 4-ACETOXY-3-METHOXYCINNAMALDEHYDE
• ARTEMISININ
• 2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE
• 3',4',7-TRIMETHOXYFLAVONE
• QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER
• 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE
• 2,4,6-Trimethoxybenzaldehyde
• QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER
• 3',4',5,7-TETRAMETHOXYFLAVONE
• 3,4-Diethoxybenzyl alcohol
• 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE
• 5,7-DIMETHOXYFLAVONE
• KAEMPFEROL-3,7,4'-TRIMETHYL ETHER
• FLAVONE
• 7-HYDROXY-5-METHOXY-2-PHENYL-CHROMEN-4-ONE
• 5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE