QUERCETINPENTAACETATE
QUERCETINPENTAACETATE Basic information
- Product Name:
- QUERCETINPENTAACETATE
- Synonyms:
-
- 3,3',4',5,7-Penta(acetyloxy)flavone
- 3,5,7-triacetoxy-2-(3,4-diacetoxy-phenyl)-chromen-4-one
- Pentaacetylquercetin
- 3,3',4',5,7-Pentaacetoxyflavone
- Quercetin acetate
- Quercetine pentaacetate
- [5,7-Diacetyloxy-2-(3,4-diacetyloxyphenyl)-4-oxochromen-3-yl] Acetate
- 4H-1-Benzopyran-4-one, 3,5,7-tris(acetyloxy)-2-[3,4-bis(acetyloxy)phenyl]-
- CAS:
- 1064-06-8
- MF:
- C25H20O12
- MW:
- 512.42
- Mol File:
- 1064-06-8.mol
QUERCETINPENTAACETATE Chemical Properties
- Melting point:
- 193 °C
- Boiling point:
- 666.4±55.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Dichloromethane, Ethyl Acetate
- form
- Solid
- color
- Beige
QUERCETINPENTAACETATE Usage And Synthesis
Description
Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in vitro (IC50 = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml). Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC50 = 8.7 μM) and PGE2 production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM. It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 μM, respectively).
Uses
[5,7-Diacetyloxy-2-(3,4-diacetyloxyphenyl)-4-oxochromen-3-yl] Acetate is an intermediate in the synthesis of Quercetin Dihydrate (Q509500), which is a lavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle.
QUERCETINPENTAACETATESupplier
- Tel
- 021-65675885 18964387627
- info@efebio.com
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
- Tel
- 400-9205774
- sales@glpbio.cn
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Tel
- 18818260767
- sales@chemegen.com
QUERCETINPENTAACETATE(1064-06-8)Related Product Information
- 7-METHOXYFLAVONOL
- Isorhamnetin
- 4-ACETOXY-3-METHOXYCINNAMALDEHYDE
- ARTEMISININ
- 2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE
- 3',4',7-TRIMETHOXYFLAVONE
- QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER
- 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE
- 2,4,6-Trimethoxybenzaldehyde
- QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER
- 3',4',5,7-TETRAMETHOXYFLAVONE
- 3,4-Diethoxybenzyl alcohol
- 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE
- 5,7-DIMETHOXYFLAVONE
- KAEMPFEROL-3,7,4'-TRIMETHYL ETHER
- FLAVONE
- 7-HYDROXY-5-METHOXY-2-PHENYL-CHROMEN-4-ONE
- 5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE