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Licochalcone B

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Licochalcone B Basic information

Product Name:
Licochalcone B
Synonyms:
  • 3,4,4'-Trihydroxy-2-Methoxychalcone
  • LICOCHALCONEB
  • (E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
  • 3,4,4'-Trihydroxy-2-methoxy-trans-chalcone
  • 2-Propen-1-one,3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
  • Licoagrochalcone B
  • (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
  • Licoricchalcone B
CAS:
58749-23-8
MF:
C16H14O5
MW:
286.28
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
58749-23-8.mol
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Licochalcone B Chemical Properties

Melting point:
196-197℃
Boiling point:
550.5±50.0 °C(Predicted)
Density 
1.369±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Store at -20°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
7.80±0.15(Predicted)
color 
White
biological source
plant
Water Solubility 
water: slightly soluble
InChI
InChI=1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+
InChIKey
DRDRYGIIYOPBBZ-XBXARRHUSA-N
SMILES
C(C1=CC=C(O)C=C1)(=O)/C=C/C1=CC=C(O)C(O)=C1OC
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Licochalcone B Usage And Synthesis

Chemical Properties

Licochalcone B is a yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents,and it is derived from licorice rhizomes.

Uses

Licochalcone B has anti-tumor, anti-inflammatory, and antioxidant effects.It can be used for content determination, identification, pharmacological experiments, etc.

Definition

ChEBI: Licochalcone B is a member of chalcones.

Biological Activity

Licochalcone B is extracted from Glycyrrhizainflate root. LICOCHALCONEB inhibits the self-aggregation of amyloid β (Aβ420) (IC50=2.16 μM) and disintegrates pre-formed Aβ42 fibrils, reducing metal-induced Aβ42 aggregation by chelating metal ions.

in vivo

Licochalcone B (1-25 mg/kg, oral gavage) alleviates oxidative stress of hepatotoxicity in mice induced by CCl4[5].

Animal Model:Mice induced by CCl4[5]
Dosage:1, 5, 25 mg/kg
Administration:Oral gavage.
Result:Elevated the levels of SOD and GSH, and reduced the GSSG levels.

IC 50

NLRP3

Licochalcone BSupplier

Chengdu RefMedic Biotech Co Ltd Gold
Tel
028-82253651 18140204969
Email
sales@refmedic.com
Hubei CuiRan Biotechnology Co., Ltd. Gold
Tel
00-1816279-5156 18162795156
Email
3391961471@qq.com
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Email
chenyj@titansci.com
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Email
sales@sungening.com
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Email
800078821@qq.com
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Licochalcone B(58749-23-8)Related Product Information