Platelet Activating Factor-16 Chemical Properties

Melting point:

247 °C

storage temp. 

-20°C

solubility 

Soluble in H2O or ethanol

form 

lyophilized powder

color 

White to off-white

Water Solubility 

Soluble to 100 mM in water

BRN 

3574588

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-38-40-48/20/22

Safety Statements 

36/37-24/25-22

RIDADR 

UN 1888 6.1/PG 3

WGK Germany 

3

RTECS 

EC6060000

F 

10-21

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Platelet Activating Factor-16 Usage And Synthesis

Uses

PAF (C16) (cas# 74389-68-7) is a blood platelet-activating factor, used to study human airway smooth muscle cell line.

Uses

C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay. It may also be used to study its physicochemical properties and its interaction with peptides derived from the C-terminal domains of human apolipoprotein E.

Definition

ChEBI: A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.

General Description

C16-02:0 PC, also known as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is present in the body and it contains ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position.

Biological Activity

Endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.

Biochem/physiol Actions

Platelet-activating factor (PAF) is a pro-inflammatory agent that exhibits variety of biological and pharmacological effects. It plays a major role in initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It yields LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine) on hydrolysis by platelet-activating factor-acetylhydrolase.

storage

Store at -20°C

Platelet Activating Factor-16(74389-68-7)Related Product Information

• N-ACETYLLACTOSAMINE
• 1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3
• phosphorylcholine
• 3-O-HEXADECYL-2-ACETYL-SN-GLYCERO-1-PHOSPHOCHOLINE
• 1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE