5-FLUORO-2-THIOPHENECARBOXYLIC ACID Chemical Properties

Melting point:

139-141℃

Boiling point:

271.2±20.0 °C(Predicted)

Density 

1.527±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

3.52±0.10(Predicted)

Appearance

Off-white to yellow Solid

InChI

InChI=1S/C5H3FO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)

InChIKey

XQURBTZGKJENJS-UHFFFAOYSA-N

SMILES

C1(C(O)=O)SC(F)=CC=1

5-FLUORO-2-THIOPHENECARBOXYLIC ACID Usage And Synthesis

Application

5-Fluorothiophene-2-carboxylic acid is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.

Synthesis

General procedure for the synthesis of 5-fluorothiophene-2-carboxylic acid from 5-fluorothiophene-2-carbonitrile: 138 mg (1.07 mmol) of 5-fluorothiophene-2-carbonitrile and 5 ml of 1N sodium hydroxide solution were added to an eggplant flask, and the mixture was heated and stirred in an oil bath at 100 °C for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature. Subsequently, 5 ml of water was added to the reaction solution for dilution and the pH was adjusted with 10 ml of 1N hydrochloric acid to 1. Next, the mixture was extracted twice with 30 ml of dichloromethane. The organic layers were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give 110 mg of 5-fluorothiophene-2-carboxylic acid.

References

[1] Patent: US6043379, 2000, A
[2] Patent: US6096901, 2000, A
[3] Patent: US2013/137730, 2013, A1. Location in patent: Paragraph 0092

5-FLUORO-2-THIOPHENECARBOXYLIC ACID(4377-58-6)Related Product Information

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