1-(1,1-Dimethylethyl)-2-methoxy-4-methylbenzene nitrated Chemical Properties

Melting point:

83°C

Odor

Sweet, yet heavy, floral-musky odor

Water Solubility 

Almost insoluble in water

EPA Substance Registry System

Benzene, 1-(1,1-dimethylethyl)-2-methoxy-4-methyl-, nitrated (73507-41-2)

Safety Information

Toxicity

The acute oral LD₅₀ in rats has been reported as 339 mg/kg (Jenner, Hagan, Taylor, Cook & Fitzhugh, 1964) and as 4.8 g/kg (4.3-5.3 g/kg) (Moreno, 1972a). The acute dermal LD₅₀ in rabbits exceeded 2 g/kg (Moreno, 1972b)

1-(1,1-Dimethylethyl)-2-methoxy-4-methylbenzene nitrated Usage And Synthesis

Description

Musk ambrette is a pale yellowish or whitish-yellow or yellow crystal (varying with crystal size and structure). Almost insoluble in water, 3.3% soluble in alcohol, 37% soluble in Diethyl phthalate, 50% soluble in Benzyl benzoate, practically insoluble in Terpenes or mineral oil. The sweet, yet heavy, floral-musky odor of excellent tenacity. The characteristic note of this Nitromusk is the floral tone of its muskiness.

Occurrence

Has apparently not been reported to occur in nature

Uses

Musk Ambrette is one of the most frequently used artificial musks. It is hard to imagine a day's work unless the jar with Musk Ambrette has been used. Musk Ambrette is used to a minor degree in flavor compositions. It finds its way into such types as Cherry, Maple, Nut, Spice, Vanilla, Mint, Fruit, etc., and has been used in trace amounts in dentifrice flavors.

Preparation

By nitration of the corresponding benzene derivative (Bedoukian, 1967).

Definition

ChEBI: Musk ambrette is a C-nitro compound.

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