2-Cyano-5-fluorobenzaldehyde Chemical Properties

Boiling point:

288.0±25.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Light yellow to light brown Solid

Safety Information

HS Code 

2926907090

2-Cyano-5-fluorobenzaldehyde Usage And Synthesis

Synthesis

To an anhydrous tetrahydrofuran (THF, 20 mL) solution of 2-bromo-4-fluorobenzonitrile (5.0 g, 25.0 mmol) was slowly added isopropylmagnesium chloride (PrMgCl, 2.0 M solution of THF, 15.0 mL, 30.0 mmol) at -30 °C. The reaction temperature was maintained at -30°C with continuous stirring for 3 hours. Subsequently, N,N-dimethylformamide (DMF, 5.80 mL, 75.0 mmol) was added to the reaction system. The reaction mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the mixture was cooled to -10 °C, 2 M hydrochloric acid (37 mL) was slowly added and stirred at this temperature for 20 min. The reaction solution was concentrated in vacuum to 1/3 of the original volume and then extracted with ethyl acetate (EtOAc, 3 times). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give the target product 4-fluoro-2-formylbenzonitrile (3.9 g, 71% yield).

References

[1] Patent: WO2011/68821, 2011, A1. Location in patent: Page/Page column 137

2-Cyano-5-fluorobenzaldehyde(894779-76-1)Related Product Information

• 2-CYANO-4-FLUOROBENZALDEHYDE
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• 4-Fluoro-3-phenoxybenzaldehyde