2-nitro-4-Bromo-5-fluorobenzoic acid Chemical Properties

Boiling point:

367.6±42.0 °C(Predicted)

Density 

1.967±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

1.68±0.25(Predicted)

form 

crystalline powder

color 

Off-white

Safety Information

HS Code 

2916399090

2-nitro-4-Bromo-5-fluorobenzoic acid Usage And Synthesis

Uses

2-nitro-4-Bromo-5-fluorobenzoic acid is an important intermediate for the synthesis of a new generation of fluoroquinolone drugs represented by ciprofloxacin.

Synthesis

2,4-Dibromo-5-fluorotoluene was brominated with NBS, hydrolyzed in acid to form aldehyde, and then oxidized by Jones reagent to obtain 2-nitro-4-Bromo-5-fluorobenzoic acid.