2,4-Dichloropyrido[3,2-d]pyrimidine Chemical Properties

Melting point:

168-169 ºC

Density 

1.573

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

-1.31±0.30(Predicted)

Appearance

Off-white to yellow Solid

InChI

InChI=1S/C7H3Cl2N3/c8-6-5-4(2-1-3-10-5)11-7(9)12-6/h1-3H

InChIKey

UVVFNZJVLRJSMW-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(Cl)=C2N=CC=CC2=N1

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

2,4-Dichloropyrido[3,2-d]pyrimidine Usage And Synthesis

Synthesis

2,4-Dichloropyrido[3,2-d]pyrimidine was synthesized using 2,4-dihydroxypyrido[3,2-d]pyrimidine as starting material in the following steps: (2) Intermediate B3 (lg) was mixed with phosphorus oxychloride (POCl3) and phosphorus pentachloride (PCl5) and reacted by refluxing at 135°C to obtain intermediate C3 in 48% yield. The reaction equation was as follows:

References

[1] Synlett, 2006, # 12, p. 1938 - 1942
[2] Patent: CN106083742, 2016, A. Location in patent: Paragraph 0185; 0188; 0189
[3] Journal of the American Chemical Society, 1956, vol. 78, p. 973,974
[4] Journal of the Chemical Society, 1956, p. 1045,1053
[5] Patent: WO2010/37765, 2010, A2. Location in patent: Page/Page column 61

2,4-Dichloropyrido[3,2-d]pyrimidine(39551-54-7)Related Product Information

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• Dichloroethane
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• 1,2-Dichloroethane
• 3,4-Dichloropyridine
• 2-Chloro-5-chloromethylpyridine
• 2,4-Dichloropyrimidine
• 2,6-Lutidine
• Clopyralid
• Chromium picolinate
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• CHEMPACIFIC 38112
• 2,4-DIBROMOBENZOTHIAZOLE
• 5-Thiazolecarboxylic acid, 2,4-dibromo-
• Pyrido[3,2-d]pyrimidine, 4-chloro-
• 2,4-Dichloropyrido[3,2-d]pyrimidine