V-PYRRO/NO Chemical Properties

Boiling point:

220.2±23.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

Flash point:

14 °C

storage temp. 

−20°C

solubility 

Ethanol

form 

Pale yellow oil.

color 

Pale Yellow

Stability:

Store in Freezer (> 1 year at -20°)

Safety Information

Hazard Codes 

F

Risk Statements 

11

Safety Statements 

7-16

RIDADR 

UN 1170 3/PG 2

WGK Germany 

1

V-PYRRO/NO Usage And Synthesis

Chemical Properties

Pale Yellow Oil

Uses

V-PYRRO/NO is a metabolically activated nitric oxide (NO) donor drug that can be used to selectively target NO delivery to the liver. The compound is metabolized by the liver, and spontaneously decomposes with a half-life of 3 seconds, liberating NO. Infusion of 30nmol/kg of V-PYRRO/NO in rats causes only a slight drop in blood pressure. At concentrations >100ug, V-PYRRO/NO increases hepatocyte viability against TNF-a-induced apoptosis by approximately 2-fold compared to cells not treated with this compound. UV/Vis: lmax: 267nm e: 9,700

Uses

V-PYRRO/NO is a metabolically activated nitric oxide (NO) donor drug that can be used to selectively target NO delivery to the liver. The compound is metabolized by the liver, and spontaneously decom poses with a half-life of 3 seconds, liberating NO. Infusion of 30nmol/kg of V-PYRRO/NO in rats causes only a slight drop in blood pressure. At concentrations >100ug, V-PYRRO/NO increases hepatocyte viability against TNF-a-induced apoptosis by approximately 2-fold compared to cells not treated with this compound.

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