N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE Chemical Properties

Melting point:

109-110℃

Boiling point:

689.4±55.0 °C(Predicted)

Density 

1.172±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Soluble in Water, DMSO, DMF

form 

powder to crystal

pka

13.90±0.40(Predicted)

color 

White to Almost white

Appearance

light beige solid

InChI

InChI=1S/C16H30N4O4S/c17-5-7-23-9-10-24-8-6-18-14(21)4-2-1-3-13-15-12(11-25-13)19-16(22)20-15/h12-13,15H,1-11,17H2,(H,18,21)(H2,19,20,22)/t12-,13-,15-/m0/s1

InChIKey

LWISPDYGRSGXME-YDHLFZDLSA-N

SMILES

C1(=O)N[C@]2([H])[C@H](CCCCC(NCCOCCOCCN)=O)SC[C@]2([H])N1

Safety Information

HS Code 

2918999090

N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE Usage And Synthesis

Description

Biotin-PEG2-amine is a biotinylation that can react with NHS ester or carboxylic acid in the presence of EDC or HATU.

Uses

Biotin-DADOO is a biotinylation reagent, which can be used to synthesize a biotin-estradiol conjugate (i.e., biotin-DADOO-estradiol) to develop a direct, broad range enzyme immunoassay to measure plasma estradiol concentrations.

References

[1] You L, et al. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5404-5408. DOI:10.1016/j.bmcl.2017.11.011

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