CALYCOSIN 7-O-GLUCOSIDE
CALYCOSIN 7-O-GLUCOSIDE Basic information
- Product Name:
- CALYCOSIN 7-O-GLUCOSIDE
- Synonyms:
-
- CALYCOSIN 7-O-GLUCOSIDE
- calycosin-o-glucopyranoside
- Calycosin-7-O-beta-D-glucoside
- calycosin-7-O-β-D-glucoside
- 3',7-Dihydroxy-4'-Methoxyisoflavone-7-beta-D-glucopyranoside
- CS-2023
- Calycosin-7-glucoside 20633-67-4
- Calycosin-7-O-b-D-glucopyranoside
- CAS:
- 20633-67-4
- MF:
- C22H22O10
- MW:
- 446.41
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- reference substance
- Iso-Flavones
- Mol File:
- 20633-67-4.mol
CALYCOSIN 7-O-GLUCOSIDE Chemical Properties
- Melting point:
- 220 - 228°C
- Boiling point:
- 745.2±60.0 °C(Predicted)
- Density
- 1.545
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.48±0.10(Predicted)
- color
- Pale Beige
- InChIKey
- WACBUPFEGWUGPB-YFUKJJPONA-N
- SMILES
- O=C1C(C2C=CC(OC)=C(O)C=2)=COC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=C12 |&1:18,19,20,22,24,r|
CALYCOSIN 7-O-GLUCOSIDE Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in methanol and ethanol, derived from the rhizome of Astragalus membranaceus.
Uses
Calycosin 7-O-β-D-glucoside is one of seven constituent in Guanjiekang (GJK) that is formed by five medicinal herbs that is used for the rheumatoid arthritis (RA).
Definition
ChEBI: Calycosin-7-O-beta-D-glucoside is a glycosyloxyisoflavone that is calycosin substituted by a beta-D-glucopyranosyl residue at position at 7 via a glycosidic linkage. It is a hydroxyisoflavone, a monosaccharide derivative, a member of 4'-methoxyisoflavones and a 7-hydroxyisoflavones 7-O-beta-D-glucoside. It is functionally related to a calycosin.
in vivo
Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model[1].
| Animal Model: | Middle cerebral artery occlusion (MCAO) male adult Sprague-Daweley rats[1] |
| Dosage: | 26.8 mg/kg |
| Administration: | Intraperitoneal injection; 26.8 mg/kg; 14 days |
| Result: | Exhibited neuroprotective effects in rats. |
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